Personal Profile

Chandrima Chatterjee

Lecturer

Pillar / Cluster: Science

Tel: +65 6499 4527
Email: punaqevzn@fhgq.rqh.ft

Biography

Dr. Chandrima Chatterjee received her undergraduate education from India. After obtaining her B.Sc. (Hons.) in Chemistry, she moved to Indian Institute of Technology to pursue her Master’s degree with specialisation in Physical Chemistry. During her Master’s program, she had the opportunity to perform a research project in the field of Biophysical Chemistry. Following completion of her M.Sc. work, she joined the PhD program at the Yale University in US and obtained her doctoral degree in Physical Chemistry. In addition to executing her research work as a graduate student, Dr. Chatterjee had the opportunity to work as a teaching assistant (TA) for the undergraduates, which turned out to be a rewarding experience. Her responsibilities as a TA spanned from delivering classroom lectures to offering trainings in the laboratory.

After finishing her PhD, Dr. Chatterjee wished to further diversify her research area and was keen on addressing issues of Biomedical importance. Consequently, for her postdoctoral studies, she joined the Department of Physiology and Biophysics at Albert Einstein College of Medicine in New York City. She was involved in investigating interactions between two different classes of protein by means of optical-based detection schemes.

Education Background

  • PhD, Physical Chemistry, Yale University, USA, 2010
  • MSc, Chemistry, Indian Institute of Technology Bombay, India, 2003
  • BSc, Chemistry, Presidency College Kolkata, India, 2001

Research Interests

Dr. Chatterjee’s research interests have always revolved around understanding complex chemical and biological phenomenon by means of various spectroscopic and optical tools. The primary area of her graduate research was physical chemistry where she elucidated excited-state proton transfer dynamics in organic molecules through the application of resonance Raman spectroscopy. This phenomenon of excited-state intramolecular proton transfer (ESIPT) has emerged as a paradigm of crucial importance for explaining diverse photochemical and biochemical events. Such concepts also have found widespread applications in various commercial endeavours, where they have been invoked to rationalise the photostability of polymers, the optical provenance of information storage techniques and the synthesis of anti-tumor agents.

For her postdoctoral studies, she undertook a project in a Biophysics laboratory, where she investigated the mechanism of interactions between microtubules (MTs) and motor proteins belonging to the kinesin-13 family by means of fluorescence polarisation microscopy (FPM), at both ensemble and single-molecule level. The structural and functional information extracted from such studies are expected to provide a deeper insight into how cells regulate MT dynamics and may lead to the development of novel strategies to control cell proliferation for the treatment of diseases, including cancer. Dr. Chatterjee is committed to an interdisciplinary approach to research and in the future intends on integrating her knowledge in physical and biophysical chemistry to develop novel optical schemes for addressing issues of chemical and biochemical importance.

Awards

  • Graduate Research Fellowship, Yale University, 2003-2010

Selected Publications and Conferences

  • Chatterjee, C., Incarvito, C. D., Burns, L. A., Vaccaro, P. H. “Electronic structure and proton transfer in ground-state hexafluoroacetylacetone,” J. Phys. Chem. A 114(24), 6630 (2010).
  • Broadbent, S. A., Burns, L. A., Chatterjee, C., Vaccaro, P. H. “Investigation of electronic structure and proton transfer in ground state acetylacetone,” Chem. Phys. Lett. 434, 31 (2007).
  • Chatterjee, C., Burns, L. A., Johnson, B. R., Vaccaro, P. H. “Electronic structure and proton transfer in excited-state hexafluoroacetylacetone,” (Revising).
  • Chatterjee, C., Asenjo, A. B., De Paoli, V. M., and Sosa, H. J. “ Kinesin-13 binding to the Microtubules involves alternating binding sites on the motor domain,” (Revising).
  • Chatterjee, C., Asenjo, A. B., De Paoli, V. M., and Sosa, H. J. “Investigating Interactions between Kinesin-13s and Microtubules by Single Molecule Fluorescence Polarization Microscopy.” Biophysical Society 55th Annual Meeting, Baltimore, MD, USA, March 2011.
  • ChatterjeeC., Wilson, S. A., Burns, L. A., Johnson, B. R., and Vaccaro, P. H. “Evidence for Hydrogen Atom Dislocation in Electronically-excited  b-Diketo Enols.” Gordon Research Conference; Electronic Spectroscopy and Dynamics, Waterville, ME, USA, July 2009.
  • Chatterjee, C., Broadbent, S. A., Burns, L. A., Johnson, B. R., and Vaccaro, P. H. “Investigating Substituent Effects on Low-Barrier Hydrogen Bonding.” 234th American Chemical Society National Meeting, Boston, MA, USA, August 2007.